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KMID : 0363220070450040354
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Korean Journal of Dermatology
2007 Volume.45 No. 4 p.354 ~ p.361
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The Expression of HOX D3 and Vascular Endothelial Growth Factor-C in Skin Tumors
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Kim Hyung-Dong
Cho Moon-Kyun
Park Young-Lip
Lee Jong-Suk
Whang Kyu-Uang
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Abstract
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Background: The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin alpha v beta3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread.
Objective: This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers.
Methods: The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget’s disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas.
Results: Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget’s disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05).
Conclusion: These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis.
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KEYWORD
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Angiogenesis, HOX D3, Lymphangiogenesis, Metastasis, VEGF-C
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